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Anti RNA Viruses Related Biomaterials

Yao Kangde,Yin Yuji,Zhang Baolian,Zhao Liguo

Strategic Study of CAE 2003, Volume 5, Issue 7,   Pages 17-23

Abstract:

The structure, reproduction, replication and transcription of RNA viruses were introduced.Antivirus strategies including design of anti - SARS drugs, RNA interference, DNA vaccine delivery systemThese examples imply the interactions of RNA viruses with proteins, DNA, and polysaccharides.It is sure that biomaterials will play a crucial role in fighting against SARS viruses and the like.

Keywords： Anti-RNA viruses     protein     DNA     polysaccharide     biomaterials    

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Ribozyme and the mechanisms that underlie RNA catalysis

Timothy J. Wilson,Yijin Liu,David M. J. Lilley

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 178-185 doi: 10.1007/s11705-016-1558-2

Abstract: Ribozymes are widespread, and catalyze some extremely important reactions in the cell. Mechanistically most fall into one of two classes, using either metal ions or general acid-base catalysis. The nucleolytic ribozymes fall into the latter class, mostly using nucleobases. A sub-set of these use a combination of guanine base plus adenine acid to catalyze the cleavage reaction. New ribozymes are still being discovered at regular intervals and we can speculate on the potential existence of ribozymes that catalyze chemistry beyond phosphoryl transfer reactions, perhaps using small-molecule coenzymes.

Keywords： RNA catalysis     RNA structure     catalytic mechanism    

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Endemicity of H9N2 and H5N1 avian influenza viruses in poultry in China poses a serious threat to poultry

Jiao HU,Xiufan LIU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 11-24 doi: 10.15302/J-FASE-2016092

Abstract: The H9N2 and H5N1 avian influenza viruses (AIVs) have been circulating in poultry in China and becomemakes them actively involved in the emergence of the novel lineages of other subtypes of influenza viruses, such as the well-known viruses of the highly pathogenic avian influenza (HPAI) H5N2 and the 2013 novel

Keywords： avian influenza virus     H9N2     H5N1     novel viruses     public health    

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HEMIPTERAN-TRANSMITTED PLANT VIRUSES: RESEARCH PROGRESS AND CONTROL STRATEGIES

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 98-109 doi: 10.15302/J-FASE-2021389

Abstract:

About 80% of plant viruses are transmitted by specific insect vectors, especially hemipterans withThis review summarizes the latest research findings on the interactions between plant viruses and insectvectors and analyzes the key factors affecting insect transmission of plant viruses from the perspectivesAdditionally, by referring to the latest applications for blocking the transmission of animal viruses, potential control strategies to prevent the transmission of insect-vectored plant viruses using RNAi

Keywords： control strategies / feeding / immunity / insect vector / microorganism / plant virus    

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Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 984-990 doi: 10.1007/s11684-022-0930-5

Abstract: Nonpharmaceutical interventions (NPIs) have been commonly deployed to prevent and control the spread of the coronavirus disease 2019 (COVID-19), resulting in a worldwide decline in influenza prevalence. However, the influenza risk in China warrants cautious assessment. We conducted a cross-sectional, sero-epidemiological study in Shandong Province, Northern China in mid-2021. Hemagglutination inhibition was performed to test antibodies against four influenza vaccine strains. A combination of descriptive and meta-analyses was adopted to compare the seroprevalence of influenza antibodies before and during the COVID-19 pandemic. The overall seroprevalence values against A/H1N1pdm09, A/H3N2, B/Victoria, and B/Yamagata were 17.8% (95% CI 16.2%–19.5%), 23.5% (95% CI 21.7%–25.4%), 7.6% (95% CI 6.6%–8.7%), and 15.0 (95% CI 13.5%–16.5%), respectively, in the study period. The overall vaccination rate was extremely low (2.6%). Our results revealed that antibody titers in vaccinated participants were significantly higher than those in unvaccinated individuals (P < 0.001). Notably, the meta-analysis showed that antibodies against A/H1N1pdm09 and A/H3N2 were significantly low in adults after the COVID-19 pandemic ( P < 0.01). Increasing vaccination rates and maintaining NPIs are recommended to prevent an elevated influenza risk in China.

Keywords： influenza virus     seroprevalence     antibody     COVID-19     cross-sectional study    

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Distribution of antibiotic resistance genes and their association with bacteria and viruses in decentralized

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 3, doi: 10.1007/s11783-021-1469-4

Abstract:

• Distribution of ARGs in decentralized sewage facilities were investigated.

Keywords： Decentralized sewage treatment facilities     Antibiotic resistance genes     Virus     Metagenomics     Network analysis    

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RNA-Based Biocontrols—A New Paradigm in Crop Protection Review

Matthew Bramlett, Geert Plaetinck, Peter Maienfisch

Engineering 2020, Volume 6, Issue 5,   Pages 522-527 doi: 10.1016/j.eng.2019.09.008

Abstract: Over the last years, the RNA interference (RNAi) process has been identified as a very promising newRNA-based active ingredients (AIs) possess a unique mode of action and can be implemented via both geneticRNA-based AIs promise to deliver the selectivity and sustainability desired in future crop protectionresearch progress toward RNA-based biocontrols against the Colorado potato beetle (CPB), corn rootwormMany challenges still exist on the road to the implementation of a broad range of RNA-based products

Keywords： RNA-based biocontrols     RNA interference (RNAi)     Colorado potato beetle (CPB)     Corn rootworm (CRW)     Soy    

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Knockdown of a Specific Circular Non-coding RNA Significantly Suppresses Osteosarcoma Progression Article

Shidong Wang, Hongliang Zhang, Bo Li, Chenglong Chen, Tingting Ren, Yi Huang, Kai Liu, Jingjing Li, Wei Guo

Engineering 2023, Volume 21, Issue 2,   Pages 187-193 doi: 10.1016/j.eng.2021.12.007

Abstract:

Osteosarcoma (OS) is a malignant mesenchymal tissue tumor known to occur in children and adolescents, and pulmonary metastasis often leads to death in these patients. The mechanism underlying OS progression remains unclear. Therefore, identifying new therapeutic targets and treatment modalities for OS is urgently needed. Abnormally expressed non-coding circular RNAs (circRNAs) are crucial for the occurrence and development of OS. The purpose of this study was to explore the expression and role of a novel circRNA circ_000203 in OS and elucidate the underlying mechanism. circ_000203 was demonstrated highly expressed in OS cell lines and tissues, and circ_000203 knockdown significantly inhibited OS progression in vitro and in vivo. Furthermore, we found that circ_000203 is a sponge of miR-26b-5p, an upstream regulator of bone morphogenetic protein receptor 2 (BMPR2). Thus, the overexpression of BMPR2 could reduce the inhibitory effect on OS progression. This indicates that knockdown of circ_000203 suppresses OS progression through microRNA (miRNA)-mediated BMPR2 downregulation. Our findings provide important insights for understanding the occurrence and development of OS. 

Keywords： Non-coding RNA     Osteosarcoma     CircRNA     Molecular mechanism     Knockdown    

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Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 166-170 doi: 10.1007/s11684-008-0030-1

Abstract: Murine Rip2 small interfering RNA (siRNA) plasmids were constructed and transfected into macrophage and
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Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers

Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin, Kankan Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 330-343 doi: 10.1007/s11684-017-0557-0

Abstract: CRNDE is a long noncoding RNA with alternative splicing and is implicated in the pathogenesis of severalFurthermore, anti-cancer drugs could efficiently repress CRNDE overexpression in cancer cell lines and

Keywords： long noncoding RNA     CRNDE     alternative splicing    

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QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE

Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 2,   Pages 306-332 doi: 10.15302/J-FASE-2023488

Abstract:

● Using visual analysis to predict the trend of natural product pest resistance.

Keywords： anti-pest activity     crop protection     insect pest     natural product     visual analysis    

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influenza virus vaccines: what can we learn from the human immune response following exposure to H7 subtype viruses

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 471-479 doi: 10.1007/s11684-017-0602-z

Abstract: Similarly, the majority of human anti-stalk monoclonal antibodies that have been isolated are directedknown about the human humoral immune response to vaccination and infection with H7 subtype influenza viruses

Keywords： universal influenza virus vaccine     hemagglutinin stalk     H7N9    

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Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 502-508 doi: 10.1007/s11684-017-0590-z

Abstract: In this review, the RNA virion-like particles of hepatitis B virus (HBV) are integrated into the lifecycle of HBV replication, and the potential significance of serum HBV RNA is systematically describedThe production of HBV RNA virion-like particles should not be blocked by NA; in this regard, serum HBV, with pregenomic RNA origination, can only be transcribed from cccDNA.to distinguish the “functional cure” characterized as serum HBsAg loss with or without anti-HBs

Keywords： chronic hepatitis B     serum HBV RNA     nucleos(t)ide analogs     virological response     para-functional cure    

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immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq

Frontiers of Medicine doi: 10.1007/s11684-023-1017-7

Abstract: By conducting single-cell RNA-seq analyses on 26 gliomas, we reported their classification into primitive

Keywords： single-cell RNA-seq     glioma     radial glia     primitive oligodendrocyte precursor cell     immune escape    

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Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene

Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 57-60 doi: 10.1007/s11684-009-0003-z

Abstract: The aim of the present study was to construct the lentiviral RNA interference (RNAi) vector of rat OBRb

Keywords： receptors     leptin     RNA interference     lentivirus vector    

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Title Author Date Type Operation

Anti RNA Viruses Related Biomaterials

Yao Kangde,Yin Yuji,Zhang Baolian,Zhao Liguo

Journal Article

Ribozyme and the mechanisms that underlie RNA catalysis

Timothy J. Wilson,Yijin Liu,David M. J. Lilley

Journal Article

Endemicity of H9N2 and H5N1 avian influenza viruses in poultry in China poses a serious threat to poultry

Jiao HU,Xiufan LIU

Journal Article

HEMIPTERAN-TRANSMITTED PLANT VIRUSES: RESEARCH PROGRESS AND CONTROL STRATEGIES

Journal Article

Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic

Journal Article

Distribution of antibiotic resistance genes and their association with bacteria and viruses in decentralized

Journal Article

RNA-Based Biocontrols—A New Paradigm in Crop Protection

Matthew Bramlett, Geert Plaetinck, Peter Maienfisch

Journal Article

Knockdown of a Specific Circular Non-coding RNA Significantly Suppresses Osteosarcoma Progression

Shidong Wang, Hongliang Zhang, Bo Li, Chenglong Chen, Tingting Ren, Yi Huang, Kai Liu, Jingjing Li, Wei Guo

Journal Article

Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Journal Article

Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers

Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin, Kankan Wang

Journal Article

QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE

Journal Article

influenza virus vaccines: what can we learn from the human immune response following exposure to H7 subtype viruses

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Journal Article

Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Journal Article

immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq

Journal Article

Construction and identification of lentiviral RNA interference vector of rat leptin receptor gene

Zhengjuan LIU, Jie BIAN, Yuchuan WANG, Yongli ZHAO, Dong YAN, Xiaoxia WANG

Journal Article